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E-M:/ Cause for Alarm Over Chemicals Levels of common fire retardants in humans are rising rapidly, especially in the U.S. Animal tests show effects on the brain



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Enviro-Mich message from Ishgooda <ishgooda@voyager.net>
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{In those tested for PBB contamination in Michigan : 
In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the median half-life was 28.7 years.}

Cause for Alarm Over Chemicals Levels of common fire retardants in humans are rising rapidly, especially in the U.S. Animal tests show effects on the brain.

By Marla Cone, Times Staff Writer
http://www.latimes.com/news/printedition/la-me-chemicals20apr20,1,2395217.story

Toxic chemicals used as flame retardants are rapidly building up in the bodies of people and wildlife around the world, approaching levels in American women and their babies that could harm developing brains, new research shows.
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RELATED:

Eliminate PBDE and PBB Flame Retardants
Toxic Materials options: Eliminate PBDE and PBB flame retardants
or equipment designed using self-extinguishing bases. Note: The ... 
www.materials4future.org/ELECTRONICS/MATRIX/TOXICMATS/nonhalflames.html


Relatively silent in literature on PBB is the accidental mix of FireMaster with animal feed in the spring of 1973.  EVERY man woman and child who lived in the state for the next year (the time at which this was exposed in the media and people warned to limit their intake of milk and meat produced in state) have high levels of PBB in their bodies.

I would like to see a study done on this population of women, many of whom (myself included) were pregnant and breast feeding.  How many of our children suffered behavioral disorders?  Were diagnosed ADHD?  Had undescended or underdeveloped male sex organs?  Suffered endometriosis, benign cystic breast disease or breast cancer? hypothryroidism?

You will note the following study is being done in Italy...(sheesh)

GEDRI Project Inventory: The Michigan PBB Cohort 20 Years Later: ... 
GEDRI Project: The Michigan PBB Cohort 20 Years Later: Endocrine Disruption? ... 2. Project
Title: The Michigan PBB Cohort 20 Years Later: Endocrine Disruption? ... 
http://endocrine.ei.jrc.it/gedri/pack_edri.FullScreen?p_rs_id=3571


PBB Unit
http://www.michigan.gov/mdch/0,1607,7-132-2945_5103_5277-14733--,00.html

In the spring of 1973 polybrominated biphenyl (PBB), a fire retardant sold under the trademark Firemaster BP-6, was inadvertently added to dairy cattle feed rather than the feed supplement Nutrimaster. The mix-up was not recognized until the spring of 1974 when PBB was identified as the substance causing death and illness in dairy cattle. During that year PBB had become widely disbursed in the agricultural food system and in the bodies of Michigan residents. The MDCH, together with the Center for Disease Control and Prevention and three other federal agencies, began a major study to assess the health effects of PBB. A health questionnaire and blood samples were collected from people affected by the feed contamination incident. The Laboratory had the responsibility to analyze several thousand samples for PBB from 1975 to 1978.   MDCH continues contact with this cohort, updates health questionnaires and collects blood samples to be analyzed by the HRA Lab.

                     John Riebow, Ph.D., Section Manager 
                     517-335-8344 
                     riebowj@michigan.gov  


Abstract
http://ehpnet1.niehs.nih.gov/docs/2000/108p147-152blanck/abstract.html
Accidental contamination of the food chain in Michigan in 1973 with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals in 1976. Serum was collected and analyzed for PBB at the time of enrollment and for targeted studies in the following years. We used the archived PBB data to study the elimination of PBB and to identify factors associated with elimination. A total of 380 women >= 16 years of age who had an initial PBB level of 2 ppb and at least two serum samples drawn when they were not pregnant were included in the analysis. The mean initial PBB level was 20.9 ppb (median 4) and mean time between the first and last measurement was 4.2 years (range 0.5-11.1). PBB was assumed to reach equilibrium in the body before substantial amounts were eliminated and before the first serum measurements were taken; therefore, the entire body was modeled as a single compartment for PBB with exponential decay. Subject-specific decay rate estimates were regressed on predictor variables including initial age, body mass index (BMI), smoking history, breast-feeding duration, and parity. In women with an initial PBB level < 10 ppb, the median half-life was 12.9 years; in those with > 10 ppb, the median half-life was 28.7 years. Decay was significantly slower among women with an initial BMI at or above the median (BMI >= 23). The calculated half-life values are estimates of decay and can be used to estimate body burden of PBB at various points in time other than at the time of serum collection. Key words: body mass index, decay, elimination, half-life, pharmacokinetics, polybrominated biphenyl. Environ Health Perspect 108:147-152 (2000). [Online 6 January 2000] 

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