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GLIN==> Seminar Announcement



NOAA/GLERL and USGS/BRD/GLSC Joint Seminar Announcement


Dr. Robert J. Letcher
Great Lakes Institute for Environmental Research (GLIER)
  and Department of Chemistry and Biochemistry
University of Windsor
Windsor, Ontario, Canada


"METHYL SULFONE AND HYDROXYLATED METABOLITES
OF POLYCHLORINATED BIPHENYLS IN MARINE WILDLIFE
AND THEIR ENDOCRINE DISRUPTION POTENTIAL"

Wednesday, January 10, 2001
10:30 - 11:30am

Location:
Main Conference Room (105)
NOAA  Great Lakes Environmental Research Lab
2205 Commonwealth Blvd.
Ann Arbor, MI

Contact:
David F. Reid
NOAA/GLERL
734-741-2019

Abstract - Methyl sulfone (MeSO2-) metabolites of polychlorinated
biphenyls (PCBs) are persistent and bioaccumulate in biota. These PCB
metabolites have emerged as an important class of environmental
contaminants in humans, a growing number of marine and terrestrial
mammals and some bird species. Hydroxylated (HO-) PCB metabolites are
retained in the blood and plasma and have been determined in humans
and a limited number of wildlife species.  Furthermore, these
metabolites are useful biomarkers of the role of metabolism in the
toxicokinetics of PCB exposure.  Recent in vitro and in vivo bioassay
screening have indicated that persistent MeSO2-PCBs and retained
OH-PCBs are potentially thyroidogenic and (anti)estrogenic in wildlife
and humans. Therefore, the endocrine activity of PCBs in vivo are
likely mediated, in part, by PCB metabolites. This presentation will
discuss and summarize existing and new information on the levels,
congener patterns and nature of MeSO2-PCB and HO-PCB metabolites in
marine-related wildlife species. The known thyroidogenic and
(anti)estrogenic activity in vitro and in vivo of persistent
MeSO2-PCBs and retained OH-PCBs is also discussed to evaluate their
potential as endocrine disrupting agents in wildlife and humans.


--

David F. Reid, Ph.D.
National Oceanic & Atmospheric Administration (NOAA)
Great Lakes Environmental Research Lab (GLERL)
2205 Commonwealth Blvd.
Ann Arbor, MI  48105-2945
Voice:  734-741-2019
FAX:    734-741-2003
Email:  reid@glerl.noaa.gov

Visit the GLERL Website:

http://www.glerl.noaa.gov



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