GLIN==> Consumption of Great Lakes fish and breast cancer

["Alex J. Sagady & Associates" <ajs@sagady.com>]

Generally negative study on Great Lakes fish consumption and breast
cancer, except for positive association for young and pre-menopausal
women
in Wisconsin at a 1.7 relative risk ratio.


Full PDF article at:  

http://ehp.niehs.nih.gov/docs/2004/112-2/toc.html

[scroll down]

Potential Exposure to PCBs, DDT, and PBDEs from Sport-Caught Fish
Consumption in Relation to Breast Cancer Risk in Wisconsin

Jane A. McElroy,1 Marty S. Kanarek,2,3 Amy
Trentham-Dietz,1,2 Stephanie A. Robert,4 John M.
Hampton,1 Polly A. Newcomb,1,5 Henry A.
Anderson,6 and Patrick L. Remington1,2
1University of Wisconsin Comprehensive Cancer Center,
2Department of Population Health Sciences, 3Gaylord
Nelson Institute for Environmental Studies, and 4School of
Social Work, University of Wisconsin, Madison, Wisconsin, USA;
5Cancer Prevention Research Program, Fred Hutchinson Cancer
Research Center, Seattle, Washington, USA; 6Wisconsin Division
of Public Health, Department of Health and Family Services, Madison,
Wisconsin, USA 

Abstract 
In Wisconsin, consumption of Great Lakes fish is an important source of
exposure to polychlorinated biphenyls (PCBs),
dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ethers
(PBDEs), and other halogenated hydrocarbons, all of which may act as
potential risk factors for breast cancer. We examined the association
between sport-caught fish consumption and breast cancer incidence as part
of an ongoing population-based case-control study. We identified breast
cancer cases 20-69 years of age who were diagnosed in 1998-2000 (n
= 1,481) from the Wisconsin Cancer Reporting System. Female controls
of similar age were randomly selected from population lists (n =
1,301). Information about all sport-caught (Great Lakes and other lakes)
fish consumption and breast cancer risk factors was obtained through
telephone interviews. After adjustment for known and suspected risk
factors, the relative risk of breast cancer for women who had recently
consumed sport-caught fish was similar to women who had never eaten
sport-caught fish [relative risk (RR) = 1.00; 95% confidence interval
(CI), 0.86-1.17]. Frequency of consumption and location of sport-caught
fish were not associated with an increased risk of breast cancer. Recent
consumption of Great Lakes fish was not associated with postmenopausal
breast cancer (RR = 0.78; 95% CI, 0.57-1.07), whereas risk associated
with premenopausal breast cancer was elevated (RR = 1.70; 95% CI,
1.16-2.50). In this study we found no overall association between recent
consumption of sport-caught fish and breast cancer, although there may be
an increased breast cancer risk for subgroups of women who are young
and/or premenopausal. Key words: breast cancer, DDT, Great Lakes,
PBDEs, PCBs, sport-caught fish consumption. Environ Health Perspect
112:156-162 (2004). [Online 31 October 2003]

==========================================
Alex J. Sagady & Associates        http://www.sagady.com

Environmental Enforcement, Permit/Technical Review, Public Policy,
Evidence Review and Litigation Investigation on Air, Water and
Waste/Community Environmental and Resource Protection
Prospectus at:  http://www.sagady.com/sagady.pdf

PO Box 39,  East Lansing, MI  48826-0039 
(517) 332-6971; (517) 332-8987 (fax); ajs@sagady.com
==========================================