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(Fwd) Re: Health effects data

Forwarded from Printech, administered by PNEAC.

------- Forwarded Message Follows -------
Date:          Fri, 01 May 1998 13:45:20 -0500
To:            printech@great-lakes.net, printech@great-lakes.net
From:          Gary Miller <gmiller@wmrc.hazard.uiuc.edu>
Subject:       Re: Health effects data
Reply-to:      printech@great-lakes.net


According to the Registry of Toxic Effects of Chemical Substances
(1985-6) the latest version I have the following data to contribute:

2-Propanol (Isopropyl Alcohol, Anhydrous)  -  CAS # : 67-63-0
  skin irritation (rabbit): 500 mg
  eye irritation (rabbit): 10 - 16 mg (2 studies)
  mutation/cytogenic data: rat inhalation: 1030 micrograms/cubic meter
  there are also lab studies for reproductive effects and toxicity in
mice, hamsters, guinnea pigs, rabbits,
    cats and dogs  
  In human subjects (oral exposure only is reported)
    TDLo:    223 mg/kg (hallucinations, distorted perceptions)
          14,432 mg/kg (coma)
    LDLo:  3,570 mg/kg (coma)
           5,272 mg/kg (toxic effects not yet reviewed)

Ethylene Glycol n-Butyl Ether (Glycol Ether EB)  -  CAS # : 111-76-2
  skin irritatio (rabbit): 500 mg
  eye irritation (rabbit):  18 mg
  there is also data on reproductive effects for rats, rabbits and
  mice In human subjects there is toxicity data as follows
 Inhalation: TCLo: 195 ppm (nausea or vomiting)
                   100 ppm (olfaction tumors & other eye effects,

Amonium Hydroxide Solution (10%-35% solution)  -  CAS # : 1336-21-6
  the toxicity of this may vary by concentration
  data in RTECS on human subjects are:
   inhalation: LCLo: 5,000 ppm
       TCLo:   408 ppm (fibrosis, focal; acute pulmonary edema)
  oral: LDLo: 43 mg/kg

I realize these data are dated.  If yoiu need a more complete
citation, let me know.  The RTECS database is now only available
on-line from NIOSH via subscription which we do not currently have.

Gary D. Miller
Illinois Waste Management and Research Center
One East Hazelwood Drive
Champaign, IL  61820

217/333-8942 phone
217/333-8944 fax